Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells
نویسندگان
چکیده
منابع مشابه
Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells
Expansion of mesenchymal stromal/stem cells (MSCs) used in clinical practices may be associated with accumulation of genetic instability. Understanding temporal and mechanistic aspects of this process is important for improving stem cell therapy protocols. We used γH2AX foci as a marker of a genetic instability event and quantified it in MSCs that undergone various numbers of passage (3-22). We...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.101142